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WFS1 mutations are frequent monogenic causes of juvenile-onset diabetes mellitus in Lebanon.

Human molecular genetics - 15 Dec 2008

Zalloua Pierre A, Azar Sami T, Delépine Marc, Makhoul Nadine J, Blanc Hervé, Sanyoura May, Lavergne Anne, Stankov Karmen, Lemainque Arnaud, Baz Patrick, Julier Cécile

Abstract excerpt

Most cases of juvenile-onset diabetes (JOD) are diagnosed as type 1 diabetes (T1D), for which genetic studies conducted in outbred Caucasian populations support the concept of multifactorial inheritance. However, this view may be partly challenged in particular population settings. In view of the suggestive evidence for a high prevalence of Wolfram syndrome (WFS) in Lebanon, the phenotypic variability associated...

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Identifiers

PMID: 18806274
DOI: 10.1093/hmg/ddn304

Genes

WFS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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