Article
Identification of unsuspected Wolfram syndrome cases through clinical assessment and WFS1 gene screening in type 1 diabetes mellitus patients.
Gene - 15 Jul 2015
Blanco-Aguirre Maria E, la Parra David Rivera-De, Tapia-Garcia Hugo, Gonzalez-Rodriguez Johanna, Welschen Daniela, Welskin Daniela, Arroyo-Yllanes Maria Estela, Escudero Irineo, Nuñez-Hernandez Jorge A, Medina-Bravo Patricia, Zenteno Juan C
Abstract excerpt
OBJECTIVE: Wolfram syndrome (WS) is a severe autosomal recessive pleiotropic disease primarily characterized by the association of juvenile-onset diabetes mellitus and optic atrophy. Earlier reports have shown that a proportion of WS cases may remain unrecognized due to misdiagnosis as type 1 diabetes mellitus (T1DM). The objectives of this work were to estimate the prevalence of patients fulfilling clinical...
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