Article
The chondroitin polymerase K4CP and the molecular mechanism of selective bindings of donor substrates to two active sites.
The Journal of biological chemistry - 21 Nov 2008
Sobhany Mack, Kakuta Yoshimitsu, Sugiura Nobuo, Kimata Koji, Negishi Masahiko
Abstract excerpt
Bacterial chondroitin polymerase K4CP is a multifunctional enzyme with two active sites. K4CP catalyzes alternative transfers of glucoronic acid (GlcA) and N-acetylgalactosamine (GalNAc) to elongate a chain consisting of the repeated disaccharide sequence GlcAbeta1-3GalNAcbeta1-4. Unlike the polymerization reactions of DNA and RNA and polypeptide synthesis, which depend upon templates, the monosaccharide...
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