Article
Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping.
Blood - 15 Dec 2008
Johnson David C, Corthals Sophie, Ramos Christine, Hoering Antje, Cocks Kim, Dickens Nicholas J, Haessler Jeff, Goldschmidt Harmut, Child J Anthony, Bell Sue E, Jackson Graham, Baris Dalsu, Rajkumar S Vincent, Davies Faith E, Durie Brian G M, Crowley John, Sonneveld Pieter, Van Ness Brian, Morgan Gareth J
Abstract excerpt
A venous thromboembolism (VTE) with the subsequent risk of pulmonary embolism is a major concern in the treatment of patients with multiple myeloma with thalidomide. The susceptibility to developing a VTE in response to thalidomide therapy is likely to be influenced by both genetic and environmental factors. To test genetic variation associated with treatment related VTE in patient peripheral blood DNA, we used a...
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