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Article

Genetic polymorphisms in the renin-angiotensin system and cognitive decline in Parkinson's disease.

Molecular biology reports - 1 Jul 2021

Pierzchlińska Anna, Sławek Jarosław, Mak Monika, Gawrońska-Szklarz Barbara, Białecka Monika

Abstract excerpt

BACKGROUND: Renin-angiotensin system (RAS) influences the central nervous system not only through its peripheral impact-the brain possesses its own local RAS. Studies showed altered RAS components in Parkinson's disease (PD) and their association with oxidative stress which may be linked to neurodegeneration and dementia. Moreover, the protective functions of RAS blockade antagonists against cognitive decline and...

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Identifiers

PMID: 34302265
DOI: 10.1007/s11033-021-06569-6
PMCID: PMC8301732

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