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Article

In HspA from Helicobacter pylori vicinal disulfide bridges are a key determinant of domain B structure.

FEBS letters - 15 Oct 2008

Loguercio Salvatore, Dian Cyril, Flagiello Angela, Scannella Alessandra, Pucci Piero, Terradot Laurent, Zagari Adriana

Abstract excerpt

Helicobacter pylori produces a heat shock protein A (HspA) that is unique to this bacteria. While the first 91 residues (domain A) of the protein are similar to GroES, the last 26 (domain B) are unique to HspA. Domain B contains eight histidines and four cysteines and was suggested to bind nickel. We have produced HspA and two mutants: Cys94Ala and Cys94Ala/Cys111Ala and identified the disulfide bridge pattern of...

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Identifiers

PMID: 18805417
DOI: 10.1016/j.febslet.2008.09.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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