Mitotic recombination of chromosome arm 17q as a cause of loss of heterozygosity of <i>NF1</i> in neurofibromatosis type 1‐associated glomus tumors

Abstract excerpt

Neurofibromatosis type 1 (NF1) is a common, autosomal dominant, tumor-predisposition syndrome that arises secondary to mutations in NF1. Glomus tumors are painful benign tumors that originate from the glomus body in the fingers and toes due to biallelic inactivation of NF1. We karyotyped cultures from four previously reported and one new glomus tumor and hybridized tumor (and matching germline) DNA on Illumina...

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