Fibrotic Myofibroblasts Manifest Genome-Wide Derangements of Translational Control

Abstract excerpt

BACKGROUND: As a group, fibroproliferative disorders of the lung, liver, kidney, heart, vasculature and integument are common, progressive and refractory to therapy. They can emerge following toxic insults, but are frequently idiopathic. Their enigmatic propensity to resist therapy and progress to organ failure has focused attention on the myofibroblast-the primary effector of the fibroproliferative response. We...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Inflammatory Myopathies and Dermatomyositis
• Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
• Share to Systemic Sclerosis and Related Diseases