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Article

A targeted deleterious allele of the splicing factor SCNM1 in the mouse.

Genetics - 1 Nov 2008

Howell Viive M, de Haan Georgius, Bergren Sarah, Jones Julie M, Culiat Cymbeline T, Michaud Edward J, Frankel Wayne N, Meisler Miriam H

Abstract excerpt

The auxiliary spliceosomal protein SCNM1 contributes to recognition of nonconsensus splice donor sites. SCNM1 was first identified as a modifier of the severity of a sodium channelopathy in the mouse. The most severely affected strain, C57BL/6J, carries the variant allele SCNM1R187X, which is defective in splicing the mutated donor site in the Scn8a(medJ) transcript. To further probe the in vivo function of...

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Source

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Identifiers

PMID: 18791226
DOI: 10.1534/genetics.108.094227
PMCID: PMC2581945

Genes

SCNM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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