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Article

Hepatocyte growth factor inhibits VEGF-forkhead-dependent gene expression in endothelial cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2008

Abid Md Ruhul, Nadeau Robert J, Spokes Katherine C, Minami Takashi, Li Dan, Shih Shou-Ching, Aird William C

Abstract excerpt

OBJECTIVE: Recently, we reported that the forkhead transcription factor, FKHR/FOXO1, is required for vascular endothelial growth factor (VEGF)-mediated upregulation of a number of genes in endothelial cells. Here, we tested the hypothesis that hepatocyte growth factor (HGF), a potent activator of PI3K-Akt in endothelial cells, is capable of depleting the nucleus of FKHR/FOXO1 and thus inhibiting VEGF induction of...

Read the complete abstract on PubMed

Topics

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Share to Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Box Protein O1

Share to Hepatocyte Growth Factor

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Share to Transduction, Genetic

Share to Vascular Cell Adhesion Molecule-1

Share to Vascular Endothelial Growth Factor A

Source

Open in PubMed Open full text

Identifiers

PMID: 18787186
DOI: 10.1161/ATVBAHA.108.175109
PMCID: PMC2903228

Genes

FOXO1
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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