Article
KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.
Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 2022
Soh Heun, Springer Kristen, Doci Klarita, Balsbaugh Jeremy L, Tzingounis Anastasios V
Abstract excerpt
KCNQ2 and KCNQ3 channels are associated with multiple neurodevelopmental disorders and are also therapeutic targets for neurological and neuropsychiatric diseases. For more than two decades, it has been thought that most KCNQ channels in the brain are either KCNQ2/3 or KCNQ3/5 heteromers. Here, we investigated the potential heteromeric compositions of KCNQ2-containing channels. We applied split-intein protein...
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