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Article

Mutated glutathione-S-transferase reduced airway inflammation by limiting oxidative stress and Th2 response.

Free radical biology & medicine - 15 Nov 2008

Tripathi Prabhanshu, Singh B P, Arora Naveen

Abstract excerpt

Oxidative stress is an important factor in the pathogenesis of asthma. Furthermore, antioxidants like GST are reduced in asthma patients. In the present study, the therapeutic effects of exogenous GST and mGST were evaluated in a mice model. GST mutated at residues 21/27 has reduced IgE binding with similar enzyme activity as that of GST. To evaluate the therapeutic effects of GST, BALB/c mice were immunized and...

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Identifiers

PMID: 18786635
DOI: 10.1016/j.freeradbiomed.2008.08.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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