Article
The allele (A)(-110) in the promoter region of the HSP70-1 gene is unfavorable to longevity in women.
Biogerontology - 1 Jan 2003
Altomare K, Greco V, Bellizzi D, Berardelli M, Dato S, DeRango F, Garasto S, Rose G, Feraco E, Mari V, Passarino G, Franceschi C, De Benedictis G
Abstract excerpt
Heat shock proteins (HSPs) are crucial for maintenance of cell homeostasis and survival both during and after various stresses. The capability to cope with stress is believed to affect the chance of health and survival at organismal level. We have investigated whether the gene pool relevant to the (A/C)(-110) polymorphism in the promoter region of the HSP70-1 gene changes as the population ages and survival...
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