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Article

From hypo- to hypersuppression: effect of amino acid substitutions on the RNA-silencing suppressor activity of the Tobacco etch potyvirus HC-Pro.

Genetics - 1 Oct 2008

Torres-Barceló Clara, Martín Susana, Daròs José-Antonio, Elena Santiago F

Abstract excerpt

RNA silencing participates in several important functions: from the regulation of cell metabolism and organism development to sequence-specific antiviral defense. Most plant viruses have evolved proteins that suppress RNA silencing and that in many cases are multifunctional. Tobacco etch potyvirus (TEV) HC-Pro protein suppresses RNA silencing and participates in aphid-mediated transmission, polyprotein...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18780745
DOI: 10.1534/genetics.108.091363
PMCID: PMC2567354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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From hypo- to hypersuppression: effect of amino acid substitutions on the RNA-silencing suppressor activity of the Tobacco etch potyvirus HC-Pro.PMID 18780745Read ↗

Compensatory molecular evolution of HC-Pro, an RNA-silencing suppressor from a plant RNA virus.Semantic proximity Read ↗

A Newly Identified Virus in the Family Potyviridae Encodes Two Leader Cysteine Proteases in Tandem That Evolved Contrasting RNA Silencing Suppression Functions.Semantic proximity Read ↗

Long-distance movement and replication maintenance functions correlate with silencing suppression activity of potyviral HC-Pro.Semantic proximity Read ↗

Adaptive substitutions at two amino acids of HCPro modify its functional properties to separately increase the virulence of a potyviral chimera.Semantic proximity Read ↗

Natural self-attenuation of pathogenic viruses by deleting the silencing suppressor coding sequence for long-term plant-virus coexistenceSemantic proximity Read ↗

HCPro-mediated transmission by aphids of purified virions does not require its silencing suppression function and correlates with its ability to coat cell microtubules in loss-of-function mutant studies.Semantic proximity Read ↗

HC-Pro silencing suppressor significantly alters the gene expression profile in tobacco leaves and flowers.Semantic proximity Read ↗

Engineered Functional Redundancy Relaxes Selective Constraints upon Endogenous Genes in Viral RNA Genomes.Semantic proximity Read ↗

Role of a Synonymous Mutation at Codon 178 in P1 That Attenuates Potato Virus Y-Induced Tobacco Vein Necrosis and Its Application for Expressing Human Interferon.Semantic proximity Read ↗

The potyviral silencing suppressor HCPro recruits and employs host ARGONAUTE1 in pro-viral functions.Semantic proximity Read ↗

Requirement for HC-Pro processing during genome amplification of tobacco etch potyvirus.Semantic proximity Read ↗

Discriminating mutations of HC-Pro of zucchini yellow mosaic virus with differential effects on small RNA pathways involved in viral pathogenicity and symptom development.Semantic proximity Read ↗

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