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Engineered Functional Redundancy Relaxes Selective Constraints upon Endogenous Genes in Viral RNA Genomes.

Genome biology and evolution - 1 Jul 2018

Ambrós Silvia, de la Iglesia Francisca, Rosario Sttefany M, Butkovic Anamarija, Elena Santiago F

Abstract excerpt

Functional redundancy, understood as the functional overlap of different genes, is a double-edge sword. At the one side, it is thought to serve as a robustness mechanism that buffers the deleterious effect of mutations hitting one of the redundant copies, thus resulting in pseudogenization. At the other side, it is considered as a source of genetic and functional innovation. In any case, genetically redundant...

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PMID: 29982435
DOI: 10.1093/gbe/evy141
PMCID: PMC6059116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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