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Article

Compensatory molecular evolution of HC-Pro, an RNA-silencing suppressor from a plant RNA virus.

Molecular biology and evolution - 1 Mar 2010

Torres-Barceló Clara, Daròs José-Antonio, Elena Santiago F

Abstract excerpt

RNA silencing is a eukaryotic mechanism involved in several cellular processes, one example being a sequence-specific antiviral defense. Many plant viruses have developed counterdefensive proteins that in many instances are multifunctional, such as helper component protease (HC-Pro) of Tobacco etch virus (TEV). In a previous work, a collection of mutants with amino acid replacements in TEV HC-Pro was generated,...

Topics

Conserved Sequence
Cysteine Endopeptidases
Directed Molecular Evolution
Host-Pathogen Interactions
Mutation
Phenotype
Potyvirus
RNA Interference
Selection, Genetic
Serial Passage
Nicotiana

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Proteins

Source

Identifiers

PMID: 19906792
DOI: 10.1093/molbev/msp272

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Compensatory molecular evolution of HC-Pro, an RNA-silencing suppressor from a plant RNA virus.PMID 19906792Read ↗

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