Article
Effect of vitamin intervention on the relationship between GSTM1, smoking, and lung cancer risk among male smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 1999
Woodson K, Stewart C, Barrett M, Bhat N K, Virtamo J, Taylor P R, Albanes D
Abstract excerpt
The GSTM1 (glutathione S-transferase mu-1) null genotype is suspected of increasing an individual's susceptibility to tobacco smoke carcinogens because of impaired carcinogen detoxification. We were interested in whether there were differences in lung cancer susceptibility to smoking within the GSTM1 genotypes and the impact of antioxidant supplementation on this. For this purpose, we conducted a nested lung...
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