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Article

Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT

5 Sept 2008

Abstract excerpt

Gossypol is a polyphenolic compound originally isolated from cottonseed that has long been used successfully as a contraceptive drug for males. However, the molecular mechanism of anti-telomerase effects of gossypol is not entirely understood. In this study, we observed direct cytotoxicity and inhibition of telomerase activity with downregulation of telomerase reverse transcriptase (hTERT) expression. Gossypol...

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Share to Nuclear Structure and Function
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PMID: 18775705
DOI: 10.1016/j.febslet.2008.08.029

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