Potent inhibition of human telomerase by nitrostyrene derivatives.

doi:10.1124/mol.63.5.1117

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Article

Potent inhibition of human telomerase by nitrostyrene derivatives.

Molecular pharmacology - 1 May 2003

Kim Joo Hee, Kim Jun Hyun, Lee Gun Eui, Lee Jong Eun, Chung In Kwon

Abstract excerpt

Telomerase activity is expressed in most types of cancer cells but not in normal somatic cells, suggesting that telomerase may be an important target for cancer chemotherapy. Inhibition of telomerase results in telomere erosion, leading to the subsequent growth arrest of cancer cells followed by senescence or cell death. In this study, we screened a chemical library for the inhibition of human telomerase,...

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PMID: 12695540
DOI: 10.1124/mol.63.5.1117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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