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Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991.

Molecular cancer therapeutics - 1 Jul 2002

Seimiya Hiroyuki, Oh-hara Tomoko, Suzuki Tsuneji, Naasani Imad, Shimazaki Toshiyuki, Tsuchiya Katsutoshi, Tsuruo Takashi

Abstract excerpt

Epidemiological studies suggest potent anticancer effects of tea catechins. Previously, we have reported (I. Naasani et aL, Biochem. Biophys. Res. Commun., 249: 391-396, 1998) that epigallocatechin gallate (EGCG), a major tea catechin, strongly and directly inhibits telomerase, a ribonucleoprotein that maintains telomeres and has been implicated in tumorigenesis. Here, we describe newly synthesized compounds...

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PMID: 12479362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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