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Somatic Pairing of Chromosome 19 in Renal Oncocytoma Is Associated with Deregulated ELGN2-Mediated Oxygen-Sensing Response

4 Sept 2008

Abstract excerpt

Chromosomal abnormalities, such as structural and numerical abnormalities, are a common occurrence in cancer. The close association of homologous chromosomes during interphase, a phenomenon termed somatic chromosome pairing, has been observed in cancerous cells, but the functional consequences of somatic pairing have not been established. Gene expression profiling studies revealed that somatic pairing of...

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Share to Cancer, Hypoxia, and Metabolism
Share to Epigenetics and DNA Methylation
Share to Renal cell carcinoma treatment

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PMID: 18773095
DOI: 10.1371/journal.pgen.1000176

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