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Article

Hyaluronidase 3 (HYAL3) knockout mice do not display evidence of hyaluronan accumulation.

Matrix biology : journal of the International Society for Matrix Biology - 1 Oct 2008

Atmuri Vasantha, Martin Dianna C, Hemming Richard, Gutsol Alex, Byers Sharon, Sahebjam Solmaz, Thliveris James A, Mort John S, Carmona Euridice, Anderson Judy E, Dakshinamurti Shyamala, Triggs-Raine Barbara

Abstract excerpt

Hyaluronidases are endoglycosidases that initiate the breakdown of hyaluronan (HA), an abundant component of the vertebrate extracellular matrix. In humans, six paralogous genes encoding hyaluronidase-like sequences have been identified on human chromosomes 3p21.3 (HYAL2-HYAL1-HYAL3) and 7q31.3 (SPAM1-HYAL4-HYALP1). Mutations in one of these genes, HYAL1, were reported in a patient with mucopolysaccharidosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18762256
DOI: 10.1016/j.matbio.2008.07.006

Genes

HYAL3
HYAL1
HYAL2
HYAL4
SPAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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