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Article

Most pediatric patients with essential thrombocythemia show hypersensitivity to erythropoietin in vitro, with rare JAK2 V617F-positive erythroid colonies.

Leukemia research - 1 Mar 2008

Veselovska Jitka, Pospisilova Dagmar, Pekova Sona, Horvathova Monika, Solna Renata, Cmejlova Jana, Cmejla Radek, Belickova Monika, Mihal Vladimir, Stary Jan, Divoky Vladimir

Abstract excerpt

Essential thrombocythemia (ET), a Philadelphia (Ph) chromosome negative chronic myeloproliferative disorder, is usually a disease of middle age and it is extremely rare in pediatric patients. In this report we studied 12 children diagnosed with ET and one child with thrombocytosis and family hist...

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Source

Identifiers

PMID: 17719087
DOI: 10.1016/j.leukres.2007.07.011

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17719087-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Most pediatric patients with essential thrombocythemia show hypersensitivity to erythropoietin in vitro, with rare JAK2 V617F-positive erythroid colonies.PMID 17719087Read ↗

JAK2V617F mutation and spontaneous megakaryocytic or erythroid colony formation in patients with essential thrombocythaemia (ET) or polycythaemia vera (PV).Semantic proximity Read ↗

Markers of myeloproliferative diseases in childhood polycythemia vera and essential thrombocythemia.Semantic proximity Read ↗

Pediatric patients with essential thrombocythemia are mostly polyclonal and V617FJAK2 negativeSemantic proximity Read ↗

In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: a new disease paradigm.Semantic proximity Read ↗

Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemiaSemantic proximity Read ↗

Are all cases of paediatric essential thrombocythaemia really myeloproliferative neoplasms? Analysis of a large cohortSemantic proximity Read ↗

The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia veraSemantic proximity Read ↗

The Jak2V617F mutation, PRV-1 overexpression, and EEC formation define a similar cohort of MPD patients.Semantic proximity Read ↗

Familial essential thrombocythemia with spontaneous megakaryocyte colony formation and acquired JAK2 mutations.Semantic proximity Read ↗

JAK2V617F mutation and endogenous erythroid colony formation in patients with polycythaemia vera.Semantic proximity Read ↗

Frequency and clinical features of the JAK2 V617F mutation in pediatric patients with sporadic essential thrombocythemia.Semantic proximity Read ↗

The frequency of JAK2 exon 12 mutations in idiopathic erythrocytosis patients with low serum erythropoietin levels.Semantic proximity Read ↗

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