Article
CREB3L2-PPARgamma fusion mutation identifies a thyroid signaling pathway regulated by intramembrane proteolysis.
Cancer research - 1 Sept 2008
Lui Weng-Onn, Zeng Lingchun, Rehrmann Victoria, Deshpande Seema, Tretiakova Maria, Kaplan Edwin L, Leibiger Ingo, Leibiger Barbara, Enberg Ulla, Höög Anders, Larsson Catharina, Kroll Todd G
Abstract excerpt
The discovery of gene fusion mutations, particularly in leukemia, has consistently identified new cancer pathways and led to molecular diagnostic assays and molecular-targeted chemotherapies for cancer patients. Here, we report our discovery of a novel CREB3L2-PPARgamma fusion mutation in thyroid carcinoma with t(3;7)(p25;q34), showing that a family of somatic PPARgamma fusion mutations exist in thyroid cancer....
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