Article
Association of CYP2C9 gene polymorphism with bleeding as a complication of warfarin therapy.
Collegium antropologicum - 1 Jun 2008
Samardzija Marina, Topić Elizabeta, Stefanović Mario, Zibar Lada, Samardzija Goran, Balen Sanja, Vcev Aleksandar, Domanović Dragoslav, Mirat Jure, Barbić Jerko
Abstract excerpt
The aim of this study was to determine the association of bleeding as a complication of warfarin therapy with polymorphism of CYP2C9 gene (alleles 1, 2 and 3). The CYP2C9 is the main enzyme for warfarin metabolism. Study included 181 patients receiving warfarin for at least one month. Allele 1 of CYP2C9 gene (in 94.5%) and genotype *1/*1 (57.5%) prevailed. Allele 3 was found in 12.7% patients. Bleeding...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.