Article
Association between the CYP2C9 polymorphism and the drug metabolism phenotype.
Clinical chemistry and laboratory medicine - 1 Jan 2004
Topić Elizabeta, Stefanović Mario, Samardzija Marina
Abstract excerpt
CYP2C9, an isoform of the cytochrome P450 enzyme, is involved in the metabolism of most of the drugs of choice for the treatment of thromboembolic disorders. Functional polymorphism is associated with two variant alleles (alleles *2 and *3) encoding CYP2C9 enzymes with a potentially different catalytic activity. The aim of the study was to determine the frequency of the CYP2C9 polymorphism in a representative...
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