Association between the CYP2C9 polymorphism and the drug metabolism phenotype.

doi:10.1515/CCLM.2004.014

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Article

Association between the CYP2C9 polymorphism and the drug metabolism phenotype.

Clinical chemistry and laboratory medicine - 1 Jan 2004

Topić Elizabeta, Stefanović Mario, Samardzija Marina

Abstract excerpt

CYP2C9, an isoform of the cytochrome P450 enzyme, is involved in the metabolism of most of the drugs of choice for the treatment of thromboembolic disorders. Functional polymorphism is associated with two variant alleles (alleles *2 and *3) encoding CYP2C9 enzymes with a potentially different catalytic activity. The aim of the study was to determine the frequency of the CYP2C9 polymorphism in a representative...

Topics

Adult
Aged
Aged, 80 and over
Anticoagulants
Aryl Hydrocarbon Hydroxylases
Croatia
Cytochrome P-450 CYP2C9
Female
Gene Frequency
Genotype
Hemorrhage
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Pharmacogenetics

Phenotype

Polymorphism, Genetic

Thromboembolism

Source

Open in PubMed

Identifiers

PMID: 15061384
DOI: 10.1515/CCLM.2004.014

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