Article
Polymorphisms of fibroblast growth factor receptor 4 have association with the development of prostate cancer and benign prostatic hyperplasia and the progression of prostate cancer in a Japanese population.
International journal of cancer - 1 Dec 2008
Ma Zhiyong, Tsuchiya Norihiko, Yuasa Takeshi, Inoue Takamitsu, Kumazawa Teruaki, Narita Shintaro, Horikawa Yohei, Tsuruta Hiroshi, Obara Takashi, Saito Mitsuru, Satoh Shigeru, Ogawa Osamu, Habuchi Tomonori
Abstract excerpt
Fibroblast growth factor receptor 4 (FGFR4) is a member of a family of transmembrane receptors with ligand-induced tyrosine kinase activity. The Glycine (Gly) to Arginine (Arg) polymorphism at codon 388 (Gly388Arg), which encodes an amino acid in the transmembrane part of the FGFR4 gene, was reported to be associated with an increased risk in some carcinomas. We investigated the association between the Gly388Arg...
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