Article
The mitochondrial phenotype of peripheral muscle in chronic obstructive pulmonary disease: disuse or dysfunction?
American journal of respiratory and critical care medicine - 15 Nov 2008
Picard Martin, Godin Richard, Sinnreich Michael, Baril Jacinthe, Bourbeau Jean, Perrault Hélène, Taivassalo Tanja, Burelle Yan
Abstract excerpt
RATIONALE: Peripheral muscle alterations have been recognized to contribute to disability in chronic obstructive pulmonary disease (COPD). OBJECTIVES: To describe the mitochondrial phenotype in a moderate to severe COPD population and age-matched controls. METHODS: Three primary aspects of mitochondrial function were assessed in permeabilized locomotor muscle fibers. MEASUREMENTS AND MAIN RESULTS: Respiration...
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