Article
Heterogeneity of quadriceps muscle phenotype in chronic obstructive pulmonary disease (Copd); implications for stratified medicine?
Muscle & nerve - 1 Oct 2013
Natanek Samantha A, Gosker Harry R, Slot Ilse G M, Marsh Gemma S, Hopkinson Nicholas S, Man William D-C, Tal-Singer Ruth, Moxham John, Kemp Paul R, Schols Annemie M W J, Polkey Michael I
Abstract excerpt
INTRODUCTION: Quadriceps muscle dysfunction is common in COPD. Determining, and, if possible, predicting quadriceps phenotype in COPD is important for patient stratification for therapeutic trials. METHODS: In biopsies from 114 COPD patients and 30 controls, we measured fiber size and proportion and assessed the relationship with quadriceps function (strength and endurance), clinical phenotype (lung function,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.