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Article

Changes in brain orexin levels in a rat model of depression induced by neonatal administration of clomipramine.

Journal of psychopharmacology (Oxford, England) - 1 Sept 2008

Feng P, Vurbic D, Wu Z, Hu Y, Strohl K P

Abstract excerpt

Depression is associated with a deficiency of serotonergic neurons that have been found to suppress orexinergic neurons, which in turn activate these neurons in a feedback loop. This evidence suggests that orexins may be involved in the pathology of depression. Long Evans rats were treated with clomipramine (CLI) and saline (SAL) from postnatal days 8 through 21. One set of rats from both groups was sacrificed at...

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Identifiers

PMID: 18753273
DOI: 10.1177/0269881106082899
PMCID: PMC3580265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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