Article
An assessment of the clonality of the components of canine mixed mammary tumours by mitochondrial DNA analysis.
Veterinary journal (London, England : 1997) - 1 Nov 2009
Bertagnolli Angélica C, Soares Paula, van Asch Bárbara, Amorim António, Cirnes Luis, Máximo Valdemar, Cassali Geovanni D
Abstract excerpt
The aim of this study was to investigate if mutations in the mitochondrial DNA (mtDNA) D-loop fragment control region of canine mammary mixed tumours could be used as clonal markers that identified the cell population of origin. Ten benign mixed mammary tumours and nine carcinomas arising from benign mixed tumours were microdissected and DNA from epithelial and mesenchymal tumour cells and from normal mammary...
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