Article
Unraveling the details of prion (con)formation(s): recent advances by mass spectrometry.
Current opinion in drug discovery & development - 1 Sept 2008
Principe Serena, Maras Bruno, Schininà Maria Eugenia, Pocchiari Maurizio, Cardone Franco
Abstract excerpt
Transmissible spongiform encephalopathies (TSEs), or prion diseases, are neurodegenerative disorders affecting both humans and animals. TSEs are caused by the infectious agent 'prion', which is poorly characterized and is believed to be composed of the pathological isoform--TSE-associated prion protein (PrP(TSE))--of a physiological, host-encoded protein called cellular prion protein (PrPC). Whereas it is certain...
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