Article
A role for mannose-binding lectin, a component of the innate immune system in pre-eclampsia.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Oct 2008
Than Nandor Gabor, Romero Roberto, Erez Offer, Kusanovic Juan Pedro, Tarca Adi L, Edwin Samuel S, Kim Jung-Sun, Hassan Sonia S, Espinoza Jimmy, Mittal Pooja, Mazaki-Tovi Shali, Friel Lara, Gotsch Francesca, Vaisbuch Edi, Camacho Natalia, Papp Zoltan
Abstract excerpt
PROBLEM: Mannose-binding lectin (MBL) is a pattern-recognition receptor that activates complement and modulates inflammation. Homozygosity for the most common allele of the MBL2 gene that is associated with high MBL serum concentrations is more prevalent among patients with pre-eclampsia. The objective of this study was to determine maternal plasma MBL concentrations in normal pregnant women and patients with...
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