Article
Biglycan overexpression on tooth enamel formation in transgenic mice.
Anatomical record (Hoboken, N.J. : 2007) - 1 Oct 2008
Wen Xin, Zou Yanming, Luo Wen, Goldberg Michel, Moats Rex, Conti Peter S, Snead Malcolm L, Paine Michael L
Abstract excerpt
Previously, it was shown that the volume of forming enamel of molar teeth in biglycan-null mice was greater than that in genetically matched wild-type mice. This phenotypic change appeared to result from an increase in amelogenin expression, implying that biglycan directly influences amelogenin synthesis. To determine whether biglycan overexpression resulted in decreased amelogenin expression, we engineered...
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