Article
Effect of Borrelia burgdorferi genotype on the sensitivity of C6 and 2-tier testing in North American patients with culture-confirmed Lyme disease.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Oct 2008
Wormser Gary P, Liveris Dionysios, Hanincová Klára, Brisson Dustin, Ludin Sara, Stracuzzi Vincent J, Embers Monica E, Philipp Mario T, Levin Andrew, Aguero-Rosenfeld Maria, Schwartz Ira
Abstract excerpt
BACKGROUND: A potential concern with any serologic test to detect antibodies to Borrelia burgdorferi is whether the epitopes incorporated in the test provide sufficient cross-reactivity to detect infection with all of the pathogenic strains of the species. This is a particular concern for the C6 test, which is based on reactivity to a single peptide. METHODS: C6 testing and 2-tier testing were performed on...
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