Article
The multiple-wing-hairs gene encodes a novel GBD-FH3 domain-containing protein that functions both prior to and after wing hair initiation.
Genetics - 1 Sept 2008
Yan Jie, Huen David, Morely Terri, Johnson Glynnis, Gubb David, Roote John, Adler Paul N
Abstract excerpt
The frizzled signaling/signal transduction pathway controls planar cell polarity (PCP) in both vertebrates and invertebrates. Epistasis experiments argue that in the Drosophila epidermis multiple wing hairs (mwh) acts as a downstream component of the pathway. The PCP proteins accumulate asymmetrically in pupal wing cells where they are thought to form distinct protein complexes. One is located on the distal side...
Topics
- Actins
- Alleles
- Animals
- Cloning, Molecular
- Cytoskeleton
- Drosophila Proteins
- Drosophila melanogaster
- Frizzled Receptors
- GTP-Binding Proteins
- Models, Genetic
- Mutation
- Plasmids
- Protein Structure, Tertiary