Article
Role of polymorphisms in dopamine synthesis and metabolism genes and association of DBH haplotypes with Parkinson's disease among North Indians.
Pharmacogenetics and genomics - 1 Jul 2010
Punia Sohan, Das Mitashree, Behari Madhuri, Mishra Bikash K, Sahani Asish K, Govindappa Shyla T, Jayaram Sachi, Muthane Uday B, K Thelma B, Juyal Ramesh C
Abstract excerpt
OBJECTIVES: Genetic and non-genetic components are believed to govern the etiology of common complex traits such as Parkinson's disease (PD). In view of the biochemical evidence of depleted dopamine levels in the affected brains and also the most common and effective therapeutic modality of administration of levodopa in PD, genes from the dopaminergic pathway emerge as major determinants. We have earlier shown...
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