Spermatogonial Stem Cell Self-Renewal Requires OCT4, a Factor Downregulated During Retinoic Acid-Induced Differentiation

Abstract excerpt

The long-term production of billions of spermatozoa relies on the regulated proliferation and differentiation of spermatogonial stem cells (SSCs). To date only a few factors are known to function in SSCs to provide this regulation. Octamer-4 (OCT4) plays a critical role in pluripotency and cell survival of embryonic stem cells and primordial germ cells; however, it is not known whether it plays a similar function...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Pluripotent Stem Cells Research
• Share to Reproductive Biology and Fertility
• Share to Sperm and Testicular Function