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A clinical, neuropsychological and olfactory evaluation of a large family with LRRK2 mutations.

Parkinsonism & related disorders - 1 May 2009

Lohmann Ebba, Leclere Laurence, De Anna Francesca, Lesage Suzanne, Dubois Bruno, Agid Yves, Dürr Alexandra, Brice Alexis

Abstract excerpt

We evaluated the neurological and neuropsychological profiles and olfaction as presymptomatic markers in a large family with Parkinson disease (PD) caused by the G2019S mutation in the LRRK2 gene. Five affected family members, 14 asymptomatic mutation carriers and 15 non-carriers were compared. Patients had typical dopa-responsive PD, frequently associated with cognitive impairment. Asymptomatic carriers and...

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Identifiers

PMID: 18718805
DOI: 10.1016/j.parkreldis.2008.06.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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