Article
Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jun 2008
Masuo Kazuko, Straznicky Nora E, Lambert Gavin W, Katsuya Tomohiro, Sugimoto Ken, Rakugi Hiromi, Socratous Florentia, Hastings Jacqueline, Lambert Elisabeth A, Ogihara Toshio, Esler Murray D
Abstract excerpt
Leptin plays a key role in the regulation of body weight through the sympathetic nervous system; however, the contributions of leptin-receptor polymorphisms to obesity and sympathetic nerve activity have not been fully clarified. In the present study, we examined the relationships between leptin-receptor polymorphisms, plasma leptin and whole-body norepinephrine (NE) spillover as an index of sympathetic nerve...
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