Article
Beta2-adrenoceptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic activation.
American journal of hypertension - 1 Oct 2006
Masuo Kazuko, Katsuya Tomohiro, Kawaguchi Hideki, Fu Yuxiao, Rakugi Hiromi, Ogihara Toshio, Tuck Michael L
Abstract excerpt
BACKGROUND: Obesity is a growing public health problem. It has been reported that beta2-adrenoceptor polymorphisms are associated with obesity. This study examines the associations of beta2-adrenoceptor polymorphism with relationships between plasma norepinephrine (NE) and leptin to evaluate further the mechanisms of obesity. METHODS: In 329 normotensive (BP <140/90 mm Hg) men with a wide range of BMI (17.0 to...
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