Article
The Cth2 ARE-binding protein recruits the Dhh1 helicase to promote the decay of succinate dehydrogenase SDH4 mRNA in response to iron deficiency.
The Journal of biological chemistry - 17 Oct 2008
Pedro-Segura Elisa, Vergara Sandra V, Rodríguez-Navarro Susana, Parker Roy, Thiele Dennis J, Puig Sergi
Abstract excerpt
Iron is an essential nutrient that participates as a redox co-factor in a broad range of cellular processes. In response to iron deficiency, the budding yeast Saccharomyces cerevisiae induces the expression of the Cth1 and Cth2 mRNA-binding proteins to promote a genome-wide remodeling of cellular metabolism that contributes to the optimal utilization of iron. Cth1 and Cth2 proteins bind to specific AU-rich...
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