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Article

The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase.

Cell metabolism - 5 Aug 2014

Na Un, Yu Wendou, Cox James, Bricker Daniel K, Brockmann Knut, Rutter Jared, Thummel Carl S, Winge Dennis R

Abstract excerpt

Disorders arising from impaired assembly of succinate dehydrogenase (SDH) result in a myriad of pathologies, consistent with its unique role in linking the citric acid cycle and electron transport chain. In spite of this critical function, however, only a few factors are known to be required for SDH assembly and function. We show here that two factors, Sdh6 (SDHAF1) and Sdh7 (SDHAF3), mediate maturation of the...

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Source

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Identifiers

PMID: 24954417
DOI: 10.1016/j.cmet.2014.05.014
PMCID: PMC4126850

Genes

SDHAF3
SDHAF1
SDHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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