Article
Different evolutionary rates and epidemic growth of hepatitis B virus genotypes A and D.
Virology - 10 Oct 2008
Zehender Gianguglielmo, De Maddalena Chiara, Giambelli Camilla, Milazzo Laura, Schiavini Monica, Bruno Raffaele, Tanzi Elisabetta, Galli Massimo
Abstract excerpt
The epidemiological history of HBV genotypes A and D and subgenotypes A2 and D3 was studied on 132 isolates drawn between 1980 and 2005 from patients living in a homogenous geographical area. Evolutionary rates and divergence dates were estimated and HBV demographic history was reconstructed by using a statistical approach based on coalescent theory. The evolutionary rate of A2 was significantly lower than that...
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