Article
Interindividual pharmacokinetics variability of the alpha(4)beta(1) integrin antagonist, 4-[1-[3-chloro-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidine-2-yl]methoxybenzoic acid (D01-4582), in beagles is associated with albumin genetic polymorphisms.
Journal of pharmaceutical sciences - 1 Apr 2009
Ito Takashi, Takahashi Masayuki, Sudo Kenichi, Sugiyama Yuichi
Abstract excerpt
The interindividual pharmacokinetic variability of the alpha(4)beta(1) integrin antagonist 4-[1-[3-chloro-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidine-2-yl]methoxybenzoic acid (D01-4582) was observed in beagles. The involvement of albumin genetic polymorphism in this variability was investigated. The albumin genotype was analyzed by sequencing the albumin gene from liver and blood...
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