Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1.

The Journal of clinical investigation - 1 Sept 2008

Stoltz David A, Ozer Egon A, Taft Peter J, Barry Marilyn, Liu Lei, Kiss Peter J, Moninger Thomas O, Parsek Matthew R, Zabner Joseph

Abstract excerpt

Pseudomonas aeruginosa uses quorum sensing, an interbacterial communication system, to regulate gene expression. The signaling molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) is thought to play a central role in quorum sensing. Since 3OC12-HSL can be degraded by paraoxonase (PON) family members, we hypothesized that PONs regulate P. aeruginosa virulence in vivo. We chose Drosophila melanogaster as our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Aryldialkylphosphatase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Immunity, Innate

Share to Inflammation

Share to Pseudomonas aeruginosa

Share to Pseudomonas Infections

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 18704198
DOI: 10.1172/JCI35147
PMCID: PMC2515384

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1.PMID 18704198Read ↗

Paraoxonase 1 status as a risk factor for disease or exposure.Semantic proximity Read ↗

Profiling early infection responses: <i>Pseudomonas aeruginosa</i> eludes host defenses by suppressing antimicrobial peptide gene expressionSemantic proximity Read ↗

A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes.Semantic proximity Read ↗

Virulence on the Fly: Drosophila melanogaster as a Model Genetic Organism to Decipher Host-Pathogen InteractionsSemantic proximity Read ↗

Community surveillance enhances Pseudomonas aeruginosa virulence during polymicrobial infection.Semantic proximity Read ↗

Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa infectionSemantic proximity Read ↗

A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism.Semantic proximity Read ↗

Massively parallel mutant selection identifies genetic determinants of <i>Pseudomonas aeruginosa</i> colonization of <i>Drosophila melanogaster</i>Semantic proximity Read ↗

The<i>Drosophila melanogaster</i>Toll Pathway Participates in Resistance to Infection by the Gram-Negative Human Pathogen<i>Pseudomonas aeruginosa</i>Semantic proximity Read ↗

Collaborative Cross Mice Yield Genetic Modifiers for Pseudomonas aeruginosa Infection in Human Lung Disease.Semantic proximity Read ↗

Paraoxonases-1, -2 and -3: What are their functions?Semantic proximity Read ↗

Lipopolysaccharide-mediated resistance to host antimicrobial peptides and hemocyte-derived reactive-oxygen species are the major <i>Providencia alcalifaciens</i> virulence factors in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.