Article
Detection of dental fluorosis-associated quantitative trait Loci on mouse chromosomes 2 and 11.
Cells, tissues, organs - 1 Jan 2009
Everett Eric T, Yan Dong, Weaver Marjorie, Liu Lixiang, Foroud Tatiana, Martinez-Mier E Angeles
Abstract excerpt
Systemic exposure to greater than optimal fluoride (F) can lead to dental fluorosis (DF). Parental A/J (DF-susceptible) and 129P3/J (DF-resistant) inbred mice were used for histological studies and to generate F2 progeny. Mice were treated with 0 or 50 ppm F in their drinking water for 60 days. A clinical criterion (modified Thylstrup and Fejerskov categorical scale) was used to assess the severity of DF for each...
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