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Article

Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia.

Cancer research - 15 Aug 2008

Case Marian, Matheson Elizabeth, Minto Lynne, Hassan Rosline, Harrison Christine J, Bown Nick, Bailey Simon, Vormoor Josef, Hall Andrew G, Irving Julie A E

Abstract excerpt

Deregulation of the RAS-RAF-mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK signaling cascade is often caused by somatic mutations in genes encoding proteins which influence the activity of this pathway and include NRAS, KRAS2, FLT3, PTPN11, and BRAF. We report the first comprehensive mutational screen of key exons of these genes in a large cohort of unselected acute...

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Source

Identifiers

PMID: 18701506
DOI: 10.1158/0008-5472.CAN-08-0101

Genes

BRAF
FLT3
NRAS
PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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