Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PJ34, an inhibitor of PARP-1, suppresses cell growth and enhances the suppressive effects of cisplatin in liver cancer cells

1 Jan 1994

Abstract excerpt

It has been suggested that poly(ADP-ribose) polymerase-l (PARP-l) plays an important role in DNA repair, cell death and proliferation, as well as in the stabilization of the genome. Pharmacological inhibition or genetic ablation of PARP-1 had a beneficial outcome in cancer chemotherapy since the cancer cells lacked PARP-1 and were sensitive to chemotherapeutic DNA damage. As a novel potent specific inhibitor of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PARP inhibition in cancer therapy

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18695907
DOI: 10.3892/or_00000043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

PJ34, an inhibitor of PARP-1, suppresses cell growth and enhances the suppressive effects of cisplatin in liver cancer cellsPMID 18695907Read ↗

Tumor suppressive effect of PARP1 and FOXO3A in gastric cancers and its clinical implicationsSemantic proximity Read ↗

Treatment with the PARP-inhibitor PJ34 causes enhanced doxorubicin-mediated cell death in HeLa cellsSemantic proximity Read ↗

PARP-1 Expression Influences Cancer Stem Cell Phenotype in Colorectal Cancer Depending on p53.Semantic proximity Read ↗

CP-31398 inhibits the growth of p53-mutated liver cancer cells in vitro and in vivo.Semantic proximity Read ↗

Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cellsSemantic proximity Read ↗

Growth inhibition of BEL-7404 human hepatoma cells by expression of mutant telomerase reverse transcriptase.Semantic proximity Read ↗

Reactive Oxygen Species Production Is Involved in Quercetin-Induced Apoptosis in Human Hepatoma CellsSemantic proximity Read ↗

RNA Interference Directed against Poly(ADP-Ribose) Polymerase 1 Efficiently Suppresses Human Immunodeficiency Virus Type 1 Replication in Human CellsSemantic proximity Read ↗

Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.