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Article

CP-31398 inhibits the growth of p53-mutated liver cancer cells in vitro and in vivo.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2016

He Xing-Xing, Zhang Yu-Nan, Yan Jun-Wei, Yan Jing-Jun, Wu Qian, Song Yu-Hu

Abstract excerpt

The tumor suppressor p53 is one of the most frequently mutated genes in hepatocellular carcinoma (HCC). Previous studies demonstrated that CP-31398 restored the native conformation of mutant p53 and trans-activated p53 downstream genes in tumor cells. However, the research on the application of CP-31398 to liver cancer has not been reported. Here, we investigated the effects of CP-31398 on the phenotype of HCC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26250460
DOI: 10.1007/s13277-015-3857-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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